Abstract
In order to clarify the effect of antibiotics on the hematopoietic function of bone marrow, especially on the erythrocyte series, the author studied changes in the erythrocyte count and hemoglobin content in the rabbit bone-marrow tissue culture to which various antibiotics had been added directly, and obtained the following results:
1. Antibiotics such as penicillin, chloromycetin, aureomycin, carzinophilin, actinomycin, and sarkomycin, at a concentration higher than a fixed concentration all act as to inhibit the hematopeietic function of the bone marrow.
2. The effect of such antibiotics as penicillin, dihydrostreptomycin, aureomycin and achromycin at the maximal concentration to blood cenventionally used in clinics is only slight, and the use of these antibiotics at such a concentration has hardly any inhibitory action on the hematopoietic function.
3. On the other hand, chloromycetin shows a tendency to inhibit the function at a relatively lower concentration than penicillin or dihydrostreptomycin.
