A study on the oxidative shunt of glucose metabolism in the brain

Part II. Oxidation of glucose-6-phosphate, 6-phosphogluconate and ribose-5 phosphate in the brain

Abstract

The O₂ comsumption of G 6 P, 6 P-G and R-5-P was measured in normal rabbits by Warburg manometer. G 6 P, 6 P-G and R 5-P are easily oxidated by brain cortex homogenate. The oxidation of G 6 P and 6-P-G was more accelerated by the addition of TPN. From the facts mentioned above, the Warburg Dickens scheme of the brain can not be disregarded.