Abstract
1) Cerebral pyruvate metabolism was experimentally studied by Inoue's cerebral irrigation method, which was considered to enable the study performed in the state most similar to the vital body.
2) The pyruvate as well as the citrate in the irrigating fluid considerably increased by irrigation of the fluid (blood three times diluted by Ringer's solution) without adding any pyruvate.
3) In case of adding 6 mg pyruvate to 90 ml of the irrigating fluid, the pyruvated decreased while the citrate increased.
4) The above-stated changes of the pyruvate and the citrate were discussed.
