Abstract
By injectiug the bovine hemoglobin (previously mixed with anti-hemoglobin serum and left stanbing for two hours) into the subcutaneous tissue on the inner side of the rabbit femur, the author studied changes of the globin serologically and also pursued histochemically the course taken by the decomposition of the heme. The following are the results.
1. The globin degenerated by anti-hemoglobin serum returns to the normalcy gradually after the injection into the tissue.
2. As the degeneration of the globin recovers, the heme is broken up from hemosiderin to bilirubin and then to bilifuscin, bnt no processes such as the liberation of heme accompanying the degeneration of the globin and subsequent decomposition of it can be recognized.
3. The globin is liberated as the decomposition of the heme proceeds and it is held in the tissue for a long time, but the decomposed product of the heme are absorbed rather quickly.
