肝炎時の脾腫竝に肝循環に関する研究

第3編 実験的肝障碍時に於ける門脈圧及び肝内血管に及ぼす副腎皮質Homrone, その外二,三の薬剤の影響に就いて

抄録

In observing the influences of injections of DOCA, cortisone, ACTH, and droplet intravenous injection of sugar-regulating agent on the changes of blood pressures in closed hepatic venous capillaries as well as on the intrahepatic portal veins, in the mature dogs with acute hepatic disturbances induced by administering allyl formate, the author obtained the following results.
1. After intramuscular injections of 2 mg/kg DOCA, 20 mg/kg cortisone, 2 IU/kg ACTH, or droplet intravenous injection of 50 cc/kg sugar regulating agent, each into normal mature dogs, there can be observed no influences on the pressures of portal veins and closed hepatic venous capillaries as well as on picture of intrahepatic capillaries.
2. When 2 mg/kg DOCA, 20 mg/kg cortisone, or 2 IU/kg ACTH is injected intramuscularly into the dogs given a subcutaneous injection of 0.04 cc/kg allyl formate one hour previously, the rising tendency of the portal pressure and closed hepatic venous capillary pressures is inhibited, and moreover, the roentgenogram of intrahepatic capillaries reveals a slight improvement in the direction of blood vessels, especially the shadow of peripheral capillaries. Furthermore, DOCA shows the most prompt and effective action, while the effect of ACTH appears slightly later.
3. When influences of droplet intravenous injection of 50 cc/kg sugar regulating agent on the portal pressure, closed hepatic venous capillaries pressues and intrahepatic capillary picture are similarly observed, no improvement can at all be recognized in the hepatic circulatory disturbances in allyl formate poisoning.