20-Methylcholanthreneによるハツカネズミリンパ性腫瘍の研究
第1編 末梢血液像に関する研究
1960 年 72 巻 4 号 p. 1133-1154
詳細
1960 年 72 巻 4 号 p. 1133-1154
(1) By painting the skin of 84 mice of uncertain origin with 20-methylcholanthrene dissolved in the 0.5-1.5% benzene solution, it was possible to observe that lymphoid tumors developed in 16.7% of the test animals. The latent period was 87 days in average. The life span of the mice with lymphoid tumors was 29 days in average, and the lymphoid tumors were consisted of lymphocytic leukemia and lymphocytic leukosarcomatosis.
(2) As for the changes of the peripheral blood pictures of the mice with lymphocytic leukemia, the author recognized leucopenia, lymphopenia, an increase in the number of large lymphocytes, eosinophilia, and appearance of erythroblasts in the preleukemic stage, and also leucocytosis, lymphocytosis, and appearance of lymphoblasts in the leukemic stage.
(3) The leukemic infiltration was observed in various organs including spleen, lymph nodes, thymus, bone marrow, etc.
(4) The author succeeded in transplanting the lymphoid tumors also to other group of mice of uncertain origin.
