制癌剤の担癌体に及ぼす影響に関する研究

第1編 胃癌に対する術前制癌剤投与による副作用の防止に関する臨床的研究

抄録

194 patients with carcinoma of the stomach being admitted in our surgical department from September 1959 to December 1960 is studied. They are divided into two groups; the treated group with blood and fluid-transfusion and the untreated.
Six anti-cancer agents are administered to each group and their side effects are observed.
In the administration of one anti-cancer agent, the transfusion treatments are the most effective to the complaints; thirst, vertigo, headache, more effective to the loss of appetite, nausea and bleeding tendency and also effective to the generalized malaise. Also these treatments are the most effective to the hypochromia, hypoproteinemia and accelerated erythrocyte sedimentation rate, more effective to the erythrocytopenia, reduced hematocrit, prolongation of the bleeding and coagulation time, and somewhat effective to the leucopenia and thrombocytopenia.
The transfusion treatments are the most effective to the subjective complaints caused by the administration of Thio-TEPA and Carzinophilin, more to Mitomycin C and Toyomycin, in less degree to Sarkomycin and 8-Azaguanine, and the most effective to the objective symptoms by Thio-TEPA, more to Sarkomycin, 8-Azaguanine and Toyomycin and also somewhat effective to Mitomycin C and Carzinophilin.
In the administration of two anti-cancer agents, the transfnsion treatments are the most effective to the complaints; thirst and headache, more the generalized malaise and also to the loss of appetite and nausea. Also these treatments are the most effective to the erythrocytopenia, hypochromia and accelerated erythrocyte sedimentation rate, more to the leucopenia and reduced hematocrit, in less degree to the prolongation of the bleeding time and the hypoproteinemia.
The transfusion treatments are the most effective to the subjective complaints caused by the administration of Carzinophilin + Thio-TEPA, more to Mitomycin C + 8-Azaguanine and also somewhat to Sarkomycin + Thio TEPA and Mitomycin C + Thio TEPA, and the most effective to the objective symptoms by Mitomycin C + Thio TEPA, more to Sarkomycin + Thio-TEPA and also somewhat to Carzinophilin + Thio-TEPA and Mitomycin C + 8-Azaguanine.
It is confirmed that the side effects caused by the anti-cancer agents are seen in less degree in the combined medication of two different agents and their furthermore relieves are noticed by the transfusion treatment.