線維芽細胞抑制剤による悪性腫瘍の治療に関する研究

第2編 クロロキンと所謂制癌剤併用の担腫瘍動物鉄代謝に及ぼす影響について

抄録

Studies on iron metabolism, especially on organ iron were performed in mice with Bashford cancer treated by combined administration of chloroquine and several anti-tumor agents.
1) Chloroquine alone tended to inhibit the storage of non-hemin iron in the tumor tissues or organs.
2) No definite tendency was shown in the storage of non-hemin iron following administration of anti-tumor agents alone.
3) Generally, it was difficult to find a definite tendency in organs such as the liver and spleen after combined administration, but in the tumors the storage of non-hemin iron (γ/g) tended to be more inhibited by combined administration than in controls and in mice treated by anti-tumor drugs alone.
4) These data suggest that the combined chemotherapy with choroquine and several antitumor drugs exhibits more effective anti-tumor activity with respect to iron metabolism of animals bearing Bashford cancer than single administration of anti tumor drugs.