ヒトの胃,十二指腸潰瘍再生上皮の組織化学的,電子顕微鏡的研究
1972 年 84 巻 11-12 号 p. 551-574
詳細
1972 年 84 巻 11-12 号 p. 551-574
Histochemical and electron microscopic studies on the healing process in human gastric and duodenal ulcers were presented.
The material for study was obtained from 83 surgically resected stomachs, including 68 patients with gastric ulcer and 15 with duodenal ulcer. These sections were stained with PAS, PAM, Alcian-blue and Toluidine-blue.
One of the characteristic features of gastric and duodenal ulcer healing was the presence of simple regenerative epithelium advancing into on the lesion.
They were generally low columnal cells, approximately 7μ wide. In these cells, the mitotic figure was occasionally present and “Undifferentiated regenerative cell” appeared.
The gastric and duodenal ulcer resembled each other in the undifferentiated regenerative cell. These cells had short and wide microvilli. In these cells, one seldom saw the mitochondria, Golgi complex and mucin granules in contrast to numerous free ribsomes and glycogen granules.
They gradually differentiated into the various kinds of the matured epithelial cell as a part from the center of the ulcer.
