Abstract
In the previous paper*, the authors reported that the most toxic compound in thermally oxidized oil (TO) is presumably the dimer of glycerides with several fanctional groups. In this paper the authors studied the digestibility of the toxic compound and the distribution of this compound into several organs of rats.
The results obtained are as follows :
(1) From the results of feeding experiments, the digestibility of the toxic dimer was higher than that of original TO.
(2) Lipids extracted from liver, intestine, stomach and adipose tissue were fractionated by silicic acid column chromatography. After several analytical experiments (IR, TLC etc.), it was found that the toxic dimer was almost hydrolyzed to mono- or diglycerides in digestive organs. However, it was believed that a part of toxic dimer accumulated in liver and blood.
(3) A marked inactivation of the pancreatic lipase was observed when the toxic dimer was added to the substrate.
(* Yukagaku, 21, 13 (1972))
