Influence of Detergent on Pregnant Mice by Application to Skin

Abstract

Fifteen percent and 20% solutions of the detergent for kitchen-use were applied on clipped skin of pregnant mice (ICR/JCL) during pregnancy days 1 to 13 at daily dose of 0.5ml per animal. Toxicological observations of maternal bodies were performed and gross, skeletal and histological (central canal of spinal cord) abnormalities of fetuses were examined.
There was no difference and no influence between detergent treated groups, water-treated group and untreated group.