Abstract
N-Substituted aminosulfonic acid derivatives, ROC2H4N (R') (CH2) 1-2SO3M, R=C10H21, C12H25 R'= H, CH3 M=H, Na, containing long chain alkoxy group were synthesized, and their growth inhibitory activities against Gram positive, Gram negative bacilli and some fungi were compared with those of the N-substituted amino acid derivatives. The introduction of the self onic group instead of the carboxylic group to the N- (2-alkoxyethyl) amino methane or ethane carboxylic acid type amphoterics enhanced their antimicrobial activities. The number of methylene groups between amino and self onic groups influenced their antimicrobial properties, and aminomethanesulf onic acid derivatives showed stronger antimicrobial activities than aminoethanesulfonic acid derivatives. Dodecoxy group was more effective on their antimicrobial properties than the decoxy group. The antimicrobial effect of a methyl group introduced into N atom of the N-alkoxyethylaminomethanesulfonic acid was not so clear as that of a methyl group in the N-substituted amino acid type amphoterics. Moreover, aqueous solution of these amphoterics showed better surface activities at any pH environment,
