Lipid Peroxidation by Chelated Iron Compounds

Abstract

Free iron could easily be chelated with phosphate moiety in biomembrane surface and reduced enzymatically by certain membrane components or non enzymatically by ascorbate.
A model membrane lipid peroxidation induced by iron-adriamycin or iron-glycated peptide was discussed. Most probable active species for their lipid peroxidations could be iron oxygen complexes, such as Fe^V= O and Fe ^IV=O type compounds. Heme-compounds, hemoglobin, cytochrome P-450 and hematin could mainly act to decompose lipid hydroperoxides to their corresponding alkoxy radicals and hydroperoxy radicals, by which lipid peroxidation should be promoted.