Abstract
Asymmetric aldol reaction of α-isocyanocarboxylates with aldehydes was catalyzed by gold- (I) complex coordinated with a chiral ferrocenylphosphine ligand containing (dialkylaminoethyl) amino group on the ferrocene side chain, which gave optically active (up to 98% ee) 5-alkyl-trans-4-methoxycarbonyl-2-oxazolines with high enantio-and diastereoselectivity in a quantitative yield. The optically active oxazolines were readily converted into β-hydroxy-α-amino acids and their derivatives.
