Abstract
Function of n-6 polyunsaturated fatty acids are described. Phospholipid molecular species containing arachidonic acid supplied free arachidonic acid which is a precursor of thromboxane A2 during activation of human platelets. n-3 Polyunsaturated fatty acids replaced arachidonic acid of the phospholipid molecular species and decreased an platelet activation. Cardiolipin molecular species containing four linoleic acids activated cytochrome c oxidase of rat heart mitochondria. n-3 Polyunsaturated fatty acids replaced the linoleic acid of cardiolipin and decreased the activation effect. Thus, n-3 polyunsaturated fatty acids competitively inhibited the function of n-6 polyunsaturated fatty acids.
