Structures and Physiological Activity of Coumarins in Hassaku (Citrus hassahu HORT.), Zabon (C. gradis OSBECK.), and Amanatsu (C. natsudaidai) Peels

Abstract

Two coumarin derivatives were isolated from hassaku (Citrus hassaku HORT.), zabon (Citrus gradis OSBECK.) and amanatsu (Citrus natsudaidai) peeling. Their structures were determined by means of MS, ¹H-NMR and ¹³C-NMR spectroscopy.
8- (2, 3-dihydroxy-3-methylbutyl) -7-methoxycoumarin (1) and 7- [(6, 7-dihydroxy-3, 7-dimethy1-2 E-octenyl) oxy] coumarin (2) were found.
Compound (1) was intravenously injected into SHR-SP rats (1 mg/100 g body weight) with subsequent rise in blood pressure. Compound (2) was not tested owing to its poor solubility in water.