Abstract
Biomembranes consist mainly of phospholipids and proteins. In this study, a new amino lysolecithintype macromer was designed and synthesized, for the preparation of thin membranes that would be similar to biomembranes. This macromer is an artificial phospholipid having two functional groups, a vinyl group to reinforce the membrane and an amino group to introduce the polypeptide chain. It forms small liposomes of 100 nm in the diameter in water. The macromer was not vinyl-polymerized as a liposome in itself, but was copolymerized in the presence of N, N-dimethylacrylamide. Polypeptide chains could be introduced to the vinyl polymerized copolymer by NCA of γ-benzyl-L-glutamate. The peptide-grafted copolymer was also capable of forming liposomes in water.
