Glycolipid Enzyme Models. V

Hydrolysis of Amide Bonds

Abstract

Glycolipid catalysts, with sugar residues as active sites were used to hydrolyses of several amino acid derivatives possesing amide bonds. The glycolipid hydrolyzed amide bond under mild conditions and recognized substrates similarly to α-chymotrypsin. A comparison of the hydrolytic activity of the catalysts indicated the terminal part of sugar residues (methylol or carboxyl group) and structure of the linkage between a sugar residue and double-hydrocarbon chain to determine substrate selectivity to some extent.