Abstract
Synthetic Glycolipids, which contain cyclic or acyclic suger moieties connected, in some, cases, with amino acid (s), have hydrolyzing abilities as hydrolase models. Characteristics of these models are made clear in comparison with those of other models, mainly histidine derivatives substituted with higher alkyl group (s), proposed so far. That is, synthetic glycolipids are distinguished by hydrolyzing activities that they do not need coexistence of amphiphilic substance (s) which are indispensable for other hydrolase models, that they can hydrolyze not only ester bonds, but amide and glycoside bonds which are too strong to be hydrolyzed by other models, and that, in addition to recognition of D, L-configuration of amino acides, they can recognize kinds of amino acids as well as α, β-glycoside bonds. The active site of glycolipids on hydrolyses and the effect of reaction fields on hydrolyzing activities of glycolipids are also discussed.
