Abstract
Molecular-sensing methods based on signal transduction at membrane interfaces and in biological systems developed at this laboratory are introduced as the following : 1) ion-channel sensors, 2) molecular mechanism for ion-selective charge separation; basis for ion-sensing, 3) methods for functional group recognition by chemically modified STM tips, 4) surface gravimetry based on molecular recognition at the interface of crystal-growth and 5) fluorescent probe molecules for clarification of cellular mechanisms.