Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
ISSN-L : 1343-4934
Case Report
Dentinogenesis imperfecta type II: an affected family saga
Mala KambojAnil Chandra
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2007 Volume 49 Issue 3 Pages 241-244

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Abstract

Dentinogenesis imperfecta (DI) type II or hereditary opalescent dentin is inherited in simple autosomal dominant mode with high penetrance and low mutation rate. It generally affects both the deciduous and permanent dentitions. DI type II corresponds to a localized form of mesodermal dysplasia, observed in histodifferentiation. Early diagnosis and treatment are therefore, fundamental, aiming at obtaining a favourable prognosis since late intervention makes treatment more complex. We present two cases of DI type II with the disease affecting three generations of a family in India, and briefly highlight the molecular basis of this disease. (J. Oral Sci. 49, 241-244, 2007)

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© 2007 by Nihon University School of Dentistry
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