Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
ISSN-L : 1343-4934
Original Article
Cell viability and physicochemical effects of different concentrations of bismuth trioxide in a mineral trioxide aggregate cement
Karla Padrón-AlvaradoLaura A. García-MendozaJuana P. Ramírez-OrtegaJacqueline A. Rodríguez-ChavézMaría D. L. A. Moyaho-BernalJuan A. Arreguín-CanoLia A. Hoz-RodríguezAna WintergerstJesús A. Arenas-AlatorreAbigailt Flores-Ledesma
Author information

2023 Volume 65 Issue 1 Pages 10-14


Purpose: To evaluate the effect of three concentrations of bismuth trioxide (Bi2O3) on the biological and physicochemical properties of an experimental mineral trioxide aggregate-type (MTA-type) cement at different time points.

Methods: Three experimental groups with white Portland cement containing 15, 20, or 25 wt% of Bi2O3 were assessed. Cellular proliferation in human periodontal ligament fibroblasts was evaluated with an MTT assay. Radiopacity, dimensional stability, pH, and compressive strength were evaluated at different time points.

Results: Bismuth trioxide induced cell proliferation in the Bi15 and Bi25 groups in a time-dependent manner; pH was similar in all groups. Compressive strength was associated with time and bismuth concentration. Bi25 had significantly contracted at day 7 and expanded at day 14 (ANOVA P < 0.05, post hoc Tukey test P < 0.05).

Conclusion: A higher Bi2O3 concentration had a negative effect on the physical properties of the cement at all time points.

Content from these authors
© 2023 by Nihon University School of Dentistry

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
Previous article Next article