Concentrations of Ampicillin in Human Serum and Mixed Saliva Following a Single Oral Administration of Lenampicillin, and Relationship between Serum and Mixed Saliva Concentrations

Abstract

The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060μg/ml, respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r =0.71, P <0.001, was found.