Carbohydrates have a large effect on postprandial glycemic control compared to nutrient content. Therefore, if slower digestion of glucose was achieved, which would be inhibition of postprandial hyperglycemia. Recently, the mulberry leaf includes 1-deoxynojirimycin（DNJ）, which inhibit postprandial glucose absorption. In human patients, it was reported that the postprandial hyperglycemia was significantly improved after administration of mulberry leaf. However, the hypoglycemic effects for dogs are unknown. Therefore, the objective of this study was to investigate the changes in glucose and lipid metabolism after administration of mulberry leaf in healthy dogs. In 6 healthy dogs, mulberry leaf powder（0.5 g/head, DNJ: 0.97 mg/head）was administered with a high carbohydrate diet for 4 days. After 4 days, blood examination results significant reduction in blood glucose level of postprandial 30 minutes was observed in the administered group as compared with the no administered group. In addition, slightly lower trend in blood insulin level of postprandial 30 and 180 minutes was observed in the administered group as compared to the no administered group. However, no significant difference in blood triglyceride level was observed between the administered group and the no administered group. From the results, administration of mulberry leaf might inhibit postprandial elevation of blood glucose and insul in secretion in healthy dogs.
