CHROMATOGRAPHY
Online ISSN : 1348-3315
Print ISSN : 1342-8284
ISSN-L : 1342-8284
Reviews
Analytical Platforms for Mass Spectrometry-Based Proteomics
Yasushi ISHIHAMA
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JOURNALS FREE ACCESS

2019 Volume 40 Issue 3 Pages 89-97

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Abstract

Mass spectrometry-based proteomics platforms have been widely used as ‘proteome sequencers’ to characterize the proteomes of a wide range of organisms. The work-flow generally involves multiple steps of sample preparation, peptide purification/concentration/pre-fractionation, and nanoLC/MS/MS measurement. This review focuses on our contributions to the technical development of current proteomics platforms, and includes a consideration of the limitations of these systems, together with the prospects for developing superior new-generation proteome sequencers.

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© 2019 The Society for Chromatographic Sciences
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