Journal of Pesticide Science
Online ISSN : 1349-0923
Print ISSN : 1348-589X
ISSN-L : 0385-1559
The Society Award Lectures (abstract)
Studies on Neurotransmitter Receptors and Their Ligands
Yoshihisa Ozoe
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2004 Volume 29 Issue 2 Pages 134-135

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Abstract
Structure-activity relationship studies of γ-aminobutyric acid (GABA) antagonists revealed that there are structural differences between the antagonist binding sites of houseflies and rats. The results point to the feasibility of the development of safe insecticides targeting insect GABA receptors. Studies with cockroach nerve cords demonstrated unique actions of dinotefuran and benzylidene anabaseines on insect nicotinic acetylcholine (ACh) receptors. Tyramine (TA) was shown to be a bioactive amine in the silkworm, and the structures of TA receptor ligands were disclosed.
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© 2004 Pesticide Science Society of Japan
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