Abstract
The structure-activity relationships of α-cyanobenzyl 3-(2, 2-dichlorovinyl)-2, 2-dimethyl-cyclopropanecarboxylates having various substituents at the 3-position of the benzyl group have been analyzed with physicochemical substituent parameters and regression techniques. The knockdown activity with and without synergists, PB and NIA, against the housefly, Musca domestica L., is correlated to the hydrophobicity, steric bulkiness, and stereo-electronic properties of the 3-substituents. Without synergists, the variation in the knockdown activity is related to that in the lethal activity with the addition of the hydrophobic term, while with synergists, both variations are directly related to each other. Synergistic effects on the knockdown activity are not so remarkable, and these compounds are detoxified depending on the structure of the 3-substituent even under synergistic conditions.
