Structure-activity Relationships of 4-tert-Butylbenzamides and Anilides against Rice Blast

Fungicidal Activity of N-Methylbenzanilides (Part 1)

Abstract

A number of 4-tert-butylbenzamides and anilides were synthesized and their preventive activity against rice blast (Pyricularia oryzae) was studied. It was found that N-methyl-4-tert-butylbenzanilides possessed high preventive activity, which was enhanced by substitution at the ortho-position of aniline ring with groups derived from the hydroxy group. 2′-Hydroxy and 2′-ethoxycarbonyloxy derivatives of N-methyl-4-tert-butylbenzanilide were found the most active compounds.