Structure-activity Relationships of N-Aryl-4-carboxy- and N-Aryl-4-hydroxy-phthalimides in Control of Plasmodiophora Disease

Studies on N-Arylphthalimides (Part 4)

Abstract

Sixty-five N-aryl-4-carboxy- and N-aryl-4-hydroxy-phthalimides having various substituents on the N-aryl moiety were prepared, and their preventive activity against clubroot of Chinese cabbage caused by Plasmodiophora brassicae was examined. Among these compounds, only 2, 6-dialkyl derivatives showed high preventive activity, which depended on the position-specific substituent effect, and both the presence of the α-branching and the number of carbon atoms in the alkyl groups on the N-aryl ring.