Abstract
Ferimzone (proposed common name), (Z)-2′-methylacetophenone 4, 6-dimethyl-2-pyrimidinylhydrazone, is a new fungicide with curative activity, which is effective against rice blast, leaf brown spot, stem-rot, and sheath blight by foliar treatment. The possibility of replacement of the hydrazone group in the ferimzone molecule by a pyrazole ring was investigated. As a result of the present study, the structure was remarkably modified by the replacement with alkyl-substituted pyrazoles which apparently resembled the hydrazone moiety and satisfied the prerequisites to the activity. A strategy for synthesizing pyrazole isosters and their fungicidal activities are described.
