Abstract
The metabolic fates of procymidone [N-(3, 5-dichlorophenyl)-1, 2-dimethylcyclopropane-1, 2-dicarboximide, Sumilex®] in rats and mice were examined. After [phenyl-14C]procymidone was administered orally to male rats and mice at 100mg/kg, the radiocarbon was rapidly and almost completely excreted into excreta of both animals, mainly into the urine, within 7 days after administration. 14C-Levels in the blood of both species were fairly constant for 2-12hr, reaching maximum at 12hr in rats and at 2hr in mice after administration. The 14C-levels decreased with the biological half-lives of 12hr in rats and 10hr in mice from 8 to 72hr after administration. In both species, the major metabolic reactions were oxidation of one of the methyl groups to carboxylic acid via hydroxymethyl and cleavage of the imide linkage. No marked species differences in metabolism were observed.
