Abstract
SD male rats 7 weeks old were fed on a diet containing (R)-(E)-1-(2, 4-dichlorophenyl)-4, 4-dimethyl-2-(1, 2, 4-triazol-1-yl)-1-penten-3-ol (diniconazole) or phenobarbital (PB) at 0ppm or 2000ppm for 2 weeks. The compounds changed various parameters relating to liver functions. They increased in liver weight, UDP-glucuronyltransferase activity, protein content, cytochrome P-450 and b5 contents, and bile flow rate. The increased UDP-glucuronyltransferase activity and bile flow rate induced an increase in thyroxine(T4)-glucuronide excretion into bile. As a result, T4 levels in serum decreased significantly. Hypertrophy of the liver and thyroid in rats receiving a higher dose of diniconazole was attributable to the elevated liver function.
