Technical Information Summary of Toxicological Studies on Quinalphos

Abstract

Quinalphos is specified as a deleterious substance since its acute toxicity in mice and rats is high. However, irritation studies in rabbits revealed that quinalphos was a non-irritant to the eye and skin. Quinalphos was considered as a non-sensitizer and was not proved to have the potential to produce acute delayed neurotoxicity.
The depression of cholinesterase activity was observed at high doses in subchronic toxicity studies in rats and it was confirmed in chronic toxicity studies in rats and dogs. In those studies no other major abnormalities related to quinalphos administration were observed and the no-observed-effect levels were defined in the respective studies. No dose-related incidence of tumor was observed in oncogenicity studies in rats and mice, and no potential was revealed in mutagenic studies. In addition, the rat reproductive performance was not effected by quinalphos and no teratogenic potential was indicated in the studies of rats and rabbits.