Design and Drug Release Properties of Time-Controlled Release Granule Containing Metominostrobin

Studies on Controlled Release Granule Applied into Seedling Box (Part. 3)

Abstract

A novel controlled drug release system on agrochemicals, time-controlled release granule (TCRG), which is characterized as an active ingredient release with a lag time, has been developed. This TCRG has a five-layered structure composed of core, active ingredient, swelling agent and two water-insoluble polymer membranes. The release profile of TCRG showed that lag time and release rate were optionally controlled by the coated amount of a water-insoluble polymer membrane, polyvinylidene chloride (PVC) and/or by the amount of a swelling agent, acrylate starch.