Effect of White Carbon Contained in Water Insoluble Polymer Membrane of Time-Controlled Release Granule on Release Profile of Metominostrobin

Development of Time-Controlled Release Granule Containing Metominostrobin (Part 3)

Abstract

We investigated the effect of white carbon (hydrated silicon dioxide) contained in water insoluble polymer membrane on release profiles of metominostrobin from the time-controlled release granule (TCRG) containing metominostrobin. As the amount of white carbon increased, the lag time for release was shortened and the release rate became faster. Thus, the changes in both lag time and release rate were thought to be related to water permeability into the TCRG and tensile strength of the membrane induced by it. We also made a single regression model and a logistic model to predict release profile based on the amount of white carbon in TCRG using computer program NLIN procedure of SAS (Statistical Analysis Systems). As a result, the actual release profile fitted in a three parameter logistic model by non linear least-squares method.