Abstract
Results of various toxicology studies conducted for characterization of effects on human health demonstrate that chromafenozide is a pesticide with extremely low risk properties.
The acute toxicity of chromafenozide to rats, mice and rabbits corresponds to the low toxic substance group specified in the Japanese Toxic Substance Regulation Act. In irritation studies, mild eye irritation induced by the technical substance, 5% SC and 0.3% D can be remedied by eye irrigation. No eye irritation was occurred with 5% SC at field application rate (1/500 dilution). Neither dermal irritation nor dermal sensitization was observed.
Subchronic toxicity, chronic toxicity and oncogenicity studies with chromafenozide in rats, mice and dogs were revealed decreased body weight gain, mild anemia, hepatocellular hypertrophy, increased weight of the liver and spleen, and darkening in color and brown pigment deposition of the spleen without any tumorigenesis in animals received the high dose of the test substance. In the reproduction study in rats and the teratology studies in rats and rabbits, no test substance-related effects were noted. In the three mutagenicity studies chromafenozide was demonstrated to be negative. In general pharmacology studies, prolonged hexobarbital sleeping time and suppressed transportability of charcoal meal in the small intestine were characteristic of chromafenozide.
MATRIC® Flowable (5% SC) and MATRIC® Dust DL (0.3% D) were registered as insecticides containing chromafenozide as the active ingredient by Japanese Ministry of Agriculture, Forestry and Fisheries on December 27, 1999.
