Abstract
The bioconcentration of dialkyl 1, 3-dithiolan-2-ylidenemalonates in fish, Oryzias latipes L., varied from 0.68 for the dimethyl analog to 102 for the di-n-butyl analog, depending on the hydrophobicity, log P, of the compounds. Accumulation was complete within 2 days at 18°C. Following this, all the concentrations in both fish and water declined with time. The rate of decrease in the aquarium system seemed to be governed by bioconcentration at the site of metabolism in fish and by susceptibility to metabolizing enzymes. The half-life of the compounds in aqueous KOH (0.1N) increased progressively from 3min for the dimethyl analog to 60min for the di-t-butyl analog, relating well to alcoholic α-substitution or the resulting electronic effect expressed as σ*. A similar tendency was observed on the compound decrease in the aquarium.
