1983 Volume 8 Issue 3 Pages 301-308
The growth inhibiting activity of 74 N-(1-methyl-1-phenylethyl) acylamides against bulrush, Scirpus juncoides was determined with the vial test. The structure-activity relationships were analyzed with the multiple regression technique using such physicochemical substituent parameters as hydrophobic π and steric Ecs values of alkyl group of the acyl moiety. The variation in the activity was shown to be related parabolically with variation in both the hydrophobicity and steric bulkiness of the alkyl substituents. When the second largest subalkyl group at the α-position of the substituent is bulkier than methyl and the unsaturated bond in the substituent conjugates with the carbonyl group of the amide, the activity is to be lowered.
