The Journal of Physical Fitness and Sports Medicine
Online ISSN : 2186-8123
Print ISSN : 2186-8131
ISSN-L : 2186-8131
Review Article
Regulatory mechanisms of muscle fiber types and their possible interactions with external nutritional stimuli
Koichi NakazatoArata Tsutaki
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2012 年 1 巻 4 号 p. 655-664

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In this review, we briefly summarize muscle fiber types and mechanisms that regulate their expression from nutritional stimulus. To begin with, we introduce genes and their location on myosin heavy chains (MyHC). Next, we show three major transcriptional controls for MyHCs as (1) calcium signaling, (2) AMPK signaling, and (3) miRNA/anti-sense RNA regulations. Following this, we summarize possible nutrients that effect muscle fiber type transformation. The possible contributors are caloric restriction, polyphenols, and high-fat and high-protein diets. We think that nutritional intervention will be a useful way to control muscle fiber type switching. This approach could be adopted by athletes as a means to condition their muscles.

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© 2012 The Japanese Society of Physical Fitness and Sports Medicine
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