Combined association of cardiorespiratory fitness and muscle mass with prevalence of diabetes mellitus: WASEDA’S Health Study

Abstract

Although cardiorespiratory fitness (CRF) and muscle mass (MM) are inversely associated with the risk of diabetes mellitus (DM), the effect of the combination of CRF and MM is unclear. We examined the combined association of CRF and MM with DM prevalence. This cross-sectional study included 1,271 middle-aged and older adults. CRF was measured at peak oxygen uptake (VO₂peak) using a cycle ergometer. Appendicular skeletal MM (ASM)/height² was assessed using bioelectrical impedance analysis. Participants were divided into two groups through the median of CRF or MM by age group and gender, respectively. DM was determined using a self-reported questionnaire and fasting blood tests. The multivariable-adjusted odds ratios (ORs) for DM prevalence were estimated using a logistic regression model. In total, 61 participants had DM. A weak positive correlation between VO₂peak and ASM/height² was observed (r = 0.24). Compared to lower CRF or MM group, the OR (95% confidence interval) was 0.52 (0.28–0.96) or 0.47 (0.23–0.97) for the higher CRF or MM group, respectively. After further adjustment of ASM/height² for the CRF category or VO₂peak for the MM category, the association of CRF or MM was found to be slightly attenuated. Compared to lower CRF with lower MM group, ORs were 0.45 (0.19–1.08) for lower CRF with higher MM group, 0.49 (0.22–1.10) for higher CRF with lower MM group, and 0.29 (0.12–0.73) for higher CRF with higher MM group. In conclusion, both higher CRF and MM were associated with lower DM prevalence compared to both lower CRF and MM.