The Journal of Physical Fitness and Sports Medicine
Online ISSN : 2186-8123
Print ISSN : 2186-8131
ISSN-L : 2186-8131
Review Article
Control of cell differentiation by mechanical stress
Jong-Hoon ParkTakashi UshidaTakayuki Akimoto
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2013 年 2 巻 1 号 p. 49-62

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Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing gene expressions and adjusting cellular and extracellular structure. Given that mechanosensitive signaling modulates cellular functions as diverse as proliferation and differentiation, such signaling is crucial for normal tissue development and homeostasis. Here we review current evidence for the mechanical regulation of cell differentiation, specifically in musculoskeletal tissues, such as skeletal muscle, fat, bone, and cartilage.

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© 2013 The Japanese Society of Physical Fitness and Sports Medicine
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