The Journal of Physical Fitness and Sports Medicine
Online ISSN : 2186-8123
Print ISSN : 2186-8131
ISSN-L : 2186-8131
Review Article
Role of Ca2+ signaling in skeletal muscle hypertrophy and atrophy
Naoki ItoShin’ichi Takeda
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JOURNAL FREE ACCESS

2015 Volume 4 Issue 2 Pages 171-176

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Abstract
Skeletal muscle maintains an adequate volume that is commensurate with its surrounding environment. Although intracellular signaling molecules and pathways underlying the regulation of protein synthesis/degradation and subsequent muscle hypertrophy/atrophy are well studied, upstream regulators are largely unknown. In this review, we summarize the recent advances relating to the role of Ca2+ signaling as an upstream regulator of intracellular signaling pathways that regulate muscle plasticity, suggesting a new therapeutic target to control muscle mass.
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© 2015 The Japanese Society of Physical Fitness and Sports Medicine
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