Nitric Oxide-Independent cGMP Efflux in the Striatum of Rats Exposed to Carbon Monoxide as Determined by Microdialysis

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Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O₂ was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O₂, was transiently increased. A nitric oxide (NO) synthase inhibitor, N^G-nitro-L-arginine, strongly reduced the steady-state level of extracellular cGMP in the striatum, indicating a primary role of NO in cGMP production. However, it failed to suppress the CO-induced increase in extracellular cGMP in the striatum. These findings suggest that CO may stimulate cGMP production in rat striatum independently of NO and hypoxia.