Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Protective Effect of Gabapentin on N-Methyl-D-aspartate–Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
Young-Sick KimHyun-Kyung ChangJin-Woo LeeYun-Hee SungSung-Eun KimMal-Soon ShinJae-Woo YiJe-Hoon ParkHong KimChang-Ju Kim
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2009 Volume 109 Issue 1 Pages 144-147


Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons was investigated. Pre-treatment with gabapentin reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. Patch-clamp studies revealed that gabapentin significantly inhibited the NMDA receptor–activated ion current in dissociated hippocampal CA1 neurons, resulting in suppression of glutamate-induced neuronal injury. These results show that gabapentin may exert protective effects against glutamate-induced neuronal injury at least in part by inhibiting the NMDA receptor–activated ion current.

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© The Japanese Pharmacological Society 2009
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