The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

Worapat Prachasilchai; Hiroko Sonoda; Naoko Yokota-Ikeda; Katsuaki Ito; Takashi Kudo; Kazunori Imaizumi; Masahiro Ikeda

doi:10.1254/jphs.08272SC

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The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

Worapat Prachasilchai, Hiroko Sonoda, Naoko Yokota-Ikeda, Katsuaki Ito, Takashi Kudo, Kazunori Imaizumi, Masahiro Ikeda

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Keywords: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein response

JOURNAL FREE ACCESS

2009 Volume 109 Issue 2 Pages 311-314

DOI https://doi.org/10.1254/jphs.08272SC

View "Advance Publication" version (January 29, 2009).

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Abstract

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.

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