A Selective Thromboxane A2 (TXA2) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid–Induced Lung Injury in Guinea Pigs

Yoichi Ishitsuka; Hiroshi Moriuchi; Yoichiro Isohama; Hidehiro Tokunaga; Keita Hatamoto; Sumika Kurita; Mitsuru Irikura; Ken-ichi Iyama; Tetsumi Irie

doi:10.1254/jphs.09128SC

Short Communications

A Selective Thromboxane A₂ (TXA₂) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid–Induced Lung Injury in Guinea Pigs

Yoichi Ishitsuka ^†, Hiroshi Moriuchi ^†, Yoichiro Isohama ^†, Hidehiro Tokunaga ^†, Keita Hatamoto ^†, Sumika Kurita ^†, Mitsuru Irikura ^†, Ken-ichi Iyama ^†, Tetsumi Irie ^†

Author information

Yoichi Ishitsuka ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Hiroshi Moriuchi ^†
Laboratory of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Sojo University, Japan
Yoichiro Isohama ^†
Department of Chemico-Pharmacological Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Hidehiro Tokunaga ^†
Department of Surgical Pathology, Kumamoto University Hospital, Japan
Keita Hatamoto ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Sumika Kurita ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Mitsuru Irikura ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Ken-ichi Iyama ^†
Department of Surgical Pathology, Kumamoto University Hospital, Japan
Tetsumi Irie ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Author contributions

†These authors contributed equally: Yoichi Ishitsuka, Hiroshi Moriuchi, Yoichiro Isohama, Hidehiro Tokunaga, Keita Hatamoto, Sumika Kurita, Mitsuru Irikura, Ken-ichi Iyama, Tetsumi Irie

Keywords: ozagrel, oleic acid, lung injury

JOURNAL FREE ACCESS

2009 Volume 111 Issue 2 Pages 211-215

DOI https://doi.org/10.1254/jphs.09128SC

View "Advance Publication" version (September 26, 2009).

Details

Abstract

This study examined the effect of ozagrel, a thromboxane A₂ synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A₂ generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.

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