A Selective Thromboxane A2 (TXA2) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid–Induced Lung Injury in Guinea Pigs

Yoichi Ishitsuka; Hiroshi Moriuchi; Yoichiro Isohama; Hidehiro Tokunaga; Keita Hatamoto; Sumika Kurita; Mitsuru Irikura; Ken-ichi Iyama; Tetsumi Irie

doi:10.1254/jphs.09128SC

Short Communications

A Selective Thromboxane A₂ (TXA₂) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid–Induced Lung Injury in Guinea Pigs

Yoichi Ishitsuka ^†, Hiroshi Moriuchi ^†, Yoichiro Isohama ^†, Hidehiro Tokunaga ^†, Keita Hatamoto ^†, Sumika Kurita ^†, Mitsuru Irikura ^†, Ken-ichi Iyama ^†, Tetsumi Irie ^†

著者情報

Yoichi Ishitsuka ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Hiroshi Moriuchi ^†
Laboratory of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Sojo University, Japan
Yoichiro Isohama ^†
Department of Chemico-Pharmacological Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Hidehiro Tokunaga ^†
Department of Surgical Pathology, Kumamoto University Hospital, Japan
Keita Hatamoto ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Sumika Kurita ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Mitsuru Irikura ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
Ken-ichi Iyama ^†
Department of Surgical Pathology, Kumamoto University Hospital, Japan
Tetsumi Irie ^†
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
著者の貢献

†Yoichi Ishitsuka, Hiroshi Moriuchi, Yoichiro Isohama, Hidehiro Tokunaga, Keita Hatamoto, Sumika Kurita, Mitsuru Irikura, Ken-ichi Iyama, Tetsumi Irieは本研究に等しく貢献した。

キーワード: ozagrel, oleic acid, lung injury

ジャーナルフリー

2009 年 111 巻 2 号 p. 211-215

DOI https://doi.org/10.1254/jphs.09128SC

View "Advance Publication" version (September 26, 2009).

詳細

抄録

This study examined the effect of ozagrel, a thromboxane A₂ synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A₂ generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.

責任著者(Corresponding author)

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