Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice

抄録

In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl₄) (5 μl/kg, twice a week for 12 weeks). Met, when given orally in drinking water at an estimated daily dose of 25 or 50 mg/kg for 10 weeks starting 2 weeks after CCl₄ challenge, protected against CCl₄ hepatotoxicity. The results indicate that the hepatoprotection afforded by Met treatment at a dose of 25 mg/kg against CCl₄ toxicity may at least in part be mediated by the enhancement of mitochondrial glutathione redox status.