Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Suparat Khamdang; Michio Takeda; Minoru Shimoda; Rie Noshiro; Shinichi Narikawa; Xiu-Lin Huang; Atsushi Enomoto; Pawinee Piyachaturawat; Hitoshi Endou

doi:10.1254/jphs.94.197

Short Communications

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Suparat Khamdang, Michio Takeda, Minoru Shimoda, Rie Noshiro, Shinichi Narikawa, Xiu-Lin Huang, Atsushi Enomoto, Pawinee Piyachaturawat, Hitoshi Endou

著者情報

キーワード: organic anion transporter, pravastatin, cimetidine

ジャーナルフリー

2004 年 94 巻 2 号 p. 197-202

DOI https://doi.org/10.1254/jphs.94.197

詳細

抄録

We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimetidine also inhibited hOAT1/rOAT1, hOAT3/rOAT3, and hOAT4. The mode of inhibition was a combination of competitive and noncompetitive manners for hOAT1, whereas it was competitive for hOAT3. The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats. In conclusion, we have characterized pravastatin and cimetidine as OAT inhibitors.

責任著者(Corresponding author)

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