Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda; Yoko Nishinaka; Toshiyuki Arai; Hajime Segawa; Hiroko Mori; Mitsuru Nonogawa; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka Sasada

doi:10.1254/jphs.08040SC

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引用する場合も本公開記事を引用してください。

Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda, Yoko Nishinaka, Toshiyuki Arai, Hajime Segawa, Hiroko Mori, Mitsuru Nonogawa, Nobuyuki Endo, Takashi Miyoshi, Kouhei Yamashita, Masataka Sasada

著者情報

キーワード: propofol emulsion, emulsifier, singlet oxygen

ジャーナルフリー早期公開

論文ID: 08040SC

DOI https://doi.org/10.1254/jphs.08040SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 107 (2008) , No. 4 p.460

詳細

抄録

Effects of an injectable emulsion of propofol and its emulsifier on singlet oxygen (¹O₂) were examined. ¹O₂ released from activated human neutrophils was detected by chemiluminescence, and chemically generated ¹O₂ was detected by electron paramagnetic resonance (EPR). Both the propofol emulsion and the emulsifier suppressed ¹O₂ release from neutrophils. However, the emulsifier did not quench chemically generated ¹O₂, while the propofol emulsion quenched it. These results indicated that the emulsifier did not scavenge ¹O₂ released from neutrophils but inhibited ¹O₂ generation. The suppressive effects of propofol emulsion on ¹O₂ release from neutrophils consist of ¹O₂ scavenging and inhibition of ¹O₂ generation.

責任著者(Corresponding author)

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